Last updated: · Originally published September 6, 2026 · Published by Eternal Elixir
Edited by Elaine Fletcher, Researcher
Disclosure: Eternal Elixir sells supplements that compete with NatureWise. This review uses NatureWise’s own labels, supplement facts panels and prices, the published court record, and published research. We did not test NatureWise products. How we write and review content.
The short version of this NatureWise review for 2026: NatureWise is a low-priced US supplement brand built around everyday vitamins and minerals, with deep ranges of vitamin D3, magnesium and probiotics. Only two of its products overlap with a longevity routine, a Berberine Complex and an NAD+ Support Complex. Both cost $34.99 for 30 servings of 2 capsules, which is $1.17 a day, even though the product page leads with “$0.58 per capsule.” The brand also lost a false advertising case over Amazon reviews and ingredient claims from 2012 and 2013, which an appeals court upheld in 2023.
If you want cheap basics, NatureWise does them well. If you want single longevity compounds such as NMN, spermidine or calcium alpha-ketoglutarate at a clear cost per day, it doesn’t sell them. Below are the numbers, checked on NatureWise’s store in September 2026.
NatureWise Review 2026: Who the Brand Is Built For
NatureWise sells direct from its own store and on Amazon. Its store listed 132 products when we checked, 128 of them with at least one option in stock. The catalog leans heavily toward mainstream staples: many versions of vitamin D3 and D3 with K2, several magnesium forms, probiotics, omega-3, turmeric, collagen, multivitamins and sleep and stress formulas.
Prices are low. Vitamin D3 starts at $6.99 for a 30 count, magnesium glycinate at $9.99 for 30 count, and probiotics at $15.99. US orders over $50 ship free, and product pages carry a 60-day money-back guarantee.
What NatureWise does not offer is depth in longevity compounds. We found no NMN, spermidine, calcium alpha-ketoglutarate, TUDCA, pterostilbene or standalone trans-resveratrol in its product feed. That is a positioning choice, not a flaw, but it decides whether the brand belongs in your basket. If those are the compounds you are shopping for, our Ca-AKG supplement comparison and our Spermidine 10mg are examples of single-ingredient options it doesn’t carry.
The Two-Capsule Detail: What NatureWise Costs per Day
On both longevity-adjacent products, the size selector reads “$0.58 per capsule,” with “30 Servings, 2 capsules per serving” in the same line. Both figures are disclosed. But the per-capsule number is the one that sticks, and it is half the daily cost. A $34.99 bottle is a 30-day supply at label directions, or $1.17 a day.
The table puts every product on the same basis: cost per label serving, which for each of these is one day.
| Product | Bottle price | Servings per bottle | Capsules per serving | Cost per day | Actives per serving |
|---|---|---|---|---|---|
| NatureWise Berberine Complex | $34.99 | 30 | 2 | $1.17 | 1,000 mg berberine complex (550 mg berberine phytosome + 450 mg berberine HCl), 100 mg turmeric extract, 25 mg enzyme blend, 5 mg black pepper extract |
| NatureWise NAD+ Support Complex | $34.99 | 30 | 2 | $1.17 | 500 mg nicotinamide riboside hydrogen malate, 250 mg betaine, 100 mg trans-resveratrol, 100 mg Quercefit quercetin phytosome |
| Eternal Elixir Berberine HCl 500mg | $49.99 | 90 | 1 | $0.56 | 500 mg berberine HCl (20:1 extract) |
| Eternal Elixir NMN 500mg | $49.99 | 90 | 1 | $0.56 | 500 mg nicotinamide mononucleotide |
| Eternal Elixir Nicotinamide Riboside 500mg | $59.99 | 60 | 1 | $1.00 | 500 mg nicotinamide riboside chloride |
| Eternal Elixir Trans-Resveratrol 600mg | $59.99 | 90 | 1 | $0.67 | 600 mg trans-resveratrol |
Prices as of Sep 2026, from each brand’s own US store, one bottle, one-time purchase. Cost per day is bottle price divided by label servings. This is a cost comparison, not a potency one: the formulas differ, and the next two sections explain how.
Berberine: One Complex Versus One Isolate
NatureWise Berberine Complex gives 1,000 mg of a berberine complex per 2-capsule serving, split into 550 mg of berberine phytosome and 450 mg of berberine HCl, both from Indian barberry. It adds 100 mg of turmeric extract standardized to 95% curcuminoids, 25 mg of the DigeSEB Super enzyme blend and 5 mg of BioPerine black pepper extract. The label says to take the 2 capsules with food, in divided doses.
Our Berberine HCl 500mg is a single-ingredient capsule: 500 mg of berberine HCl from a 20:1 concentrate, with rice flour and a cellulose capsule, one capsule per serving.
The phytosome is not filler. Berberine is poorly absorbed by mouth, and a 2016 review in Fitoterapia concluded that its oral bioavailability has to improve before it can be widely used, because poor absorption and first-pass metabolism in the gut limit how much reaches the blood (Liu et al.). Phytosomes, which bind a compound to phospholipids, are one approach to that problem. The catch is that a phytosome’s label weight includes the phospholipid, so 550 mg of phytosome is not 550 mg of berberine. A strict milligram-for-milligram comparison between these two products isn’t possible, and any review that gives you one is guessing.
What you can compare is cost and simplicity: $1.17 a day for a berberine, turmeric and enzyme blend, or $0.56 a day for a plain isolate you can dose yourself. On dose, be clear about the research: the 2008 trial our berberine page links gave 500 mg three times a day, so our one-capsule serving is a third of that daily amount, and that trial studied people with a diagnosed condition under medical care. Talk to your doctor before taking berberine if you take prescription medication. Our berberine supplement comparison works through formats and doses in more detail.
NAD+: A Nicotinamide Riboside Blend Versus Single Precursors
NatureWise’s NAD+ Support Complex is built on 500 mg of nicotinamide riboside hydrogen malate per 2-capsule serving, with 250 mg of betaine (TMG), 100 mg of trans-resveratrol from Japanese knotweed and 100 mg of Quercefit quercetin phytosome. It is a blend, and its precursor is nicotinamide riboside (NR), not NMN. People often treat the two as interchangeable. They are different molecules, though recent human data suggest they end up in a similar place.
NR has a human evidence base of its own. In a randomized, double-blind crossover trial published in Nature Communications in 2018, 30 healthy middle-aged and older adults took 500 mg of NR chloride twice a day, 1,000 mg in total, for 6 weeks, and NR was well tolerated and raised NAD+ metabolites against placebo (Martens et al.). In 2026, a randomized, placebo-controlled study in Nature Metabolism compared three precursors in 65 healthy adults and found that 14 days of NR or NMN raised circulating NAD+ to a similar degree, while nicotinamide did not (Christen et al.).
Two things follow for buyers. The precursor you choose matters less than the dose and whether you take it consistently. And both NatureWise’s blend and our own single-ingredient NR give 500 mg of NR a day at label directions, half the 1,000 mg used in the 2018 trial. NatureWise uses the hydrogen malate form, which that trial did not test. Ours is NR chloride, the form the trial used, at half the trial’s daily amount.
We sell both precursors as single ingredients: NMN 500mg at $0.56 a day and Nicotinamide Riboside 500mg at $1.00 a day, one capsule each. Our Trans-Resveratrol 600mg covers resveratrol on its own at $0.67 a day. The NatureWise blend at $1.17 a day is fair value if you want all four of its actives in one bottle, and poor value if you only want the NR. Our NMN vs nicotinamide riboside comparison, the best NR supplements and our NAD+ supplement roundup go deeper.
The Court Case and How to Read NatureWise Ratings
Many people searching for a NatureWise review are checking the lawsuit. The brand is owned by HeartWise, Inc., which does business as NatureWise, and a competitor, Vitamins Online, sued it under the federal Lanham Act and Utah unfair competition law.
After a bench trial in the District of Utah, the court found that NatureWise had made false or misleading ingredient claims about its green coffee and garcinia cambogia products and had manipulated their Amazon reviews, including by telling employees to up-vote favorable reviews and down-vote unfavorable ones and by offering free products in exchange for reviews. It ordered NatureWise to pay its 2012 and 2013 profits from those products, $9,551,232, plus attorney fees and costs. On June 27, 2023, the US Court of Appeals for the Tenth Circuit affirmed the liability finding and the profits award, and sent the questions of punitive damages and an injunction back to the district court.
That conduct dates from more than a decade ago and involved two weight-loss products, and it tells you nothing directly about what is in a bottle bought in 2026. It does change how much weight star ratings deserve for this brand. The current store pages add little either way: when we checked, the Berberine Complex showed 4.8 stars from 5 reviews and the NAD+ Support Complex 5.0 from 1 review. For this brand, the label is better evidence than the ratings.
What the NatureWise Quality Claims Cover
NatureWise product pages show a “Committed to Quality” strip listing clean ingredients, non-GMO, manufactured in the USA, gluten free and third-party tested, and the supplement facts images for both longevity products say the capsules are made in a cGMP facility. The store menu also has a separate NSF collection, which covers only part of the catalog, so the general badges and that collection are not the same claim.
“Third-party tested” deserves a careful read, and that applies to every brand, including ours. It can mean identity testing on raw materials, potency testing of the finished batch, contaminant screening, or a mix. A badge without a published certificate of analysis is an assertion, not a document. We didn’t find batch certificates linked on the two NatureWise product pages we checked, and our own product pages don’t link batch certificates either. If a specific product matters to you, ask the seller for the certificate for your lot.
Stock was mostly good. Four products had no option in stock when we checked: Triple Strength Astaxanthin, Turmeric Curcumin Complex, the Menstrual Support Duo and Probiotics for Women. Both longevity-adjacent products were available.
NatureWise Review Verdict: Best For, Skip If
Best for: stocking everyday basics on a budget. With vitamin D3 from $6.99, magnesium glycinate from $9.99, free shipping over $50 and a 60-day guarantee, NatureWise is a sensible place to buy standard vitamins and minerals.
Skip if: you are building a longevity routine. There are two relevant products, both blends, both $1.17 a day, and the range has no NMN, spermidine, Ca-AKG, TUDCA or standalone resveratrol. If you want single compounds at known doses that you can combine yourself, this is the wrong catalog.
Eternal Elixir comes at the shelf from the other direction: fewer products, single ingredients, one capsule per serving on most of the range, and a cost per day you can work out from the price and the capsule count. For a broader plan, see our guide to the best longevity supplements or our breakdown of longevity supplement stacks. If you are comparing several mainstream brands, our Dr. Berg review, Nutricost review and Codeage review use the same cost-per-serving method.
Frequently Asked Questions
Is NatureWise a good brand?
For everyday vitamins and minerals at low prices, it is a reasonable choice, with clear supplement facts panels, free shipping over $50 and a 60-day money-back guarantee. The qualifier is its court history: in 2023 a federal appeals court upheld findings that it made false ingredient claims and manipulated Amazon reviews for two products in 2012 and 2013. Judge its products on their labels rather than their star ratings.
Who owns NatureWise?
NatureWise is a trading name of HeartWise, Inc., an Oregon corporation. The court record in Vitamins Online, Inc. v. HeartWise, Inc. names the company as HeartWise, Inc., doing business as NatureWise.
Is NatureWise third-party tested?
Its product pages carry a third-party tested badge, and the store has a separate NSF collection covering part of the range. The general badge does not say what was tested or at which stage, and we didn’t find batch certificates on the two product pages we checked. Ask for the certificate of analysis for your lot if that matters to you.
Does NatureWise sell NMN?
No. Its only NAD+ product is the NAD+ Support Complex, which uses 500 mg of nicotinamide riboside hydrogen malate blended with betaine, trans-resveratrol and quercetin. If you want NMN on its own, our NMN supplement comparison covers the options, including our NMN 500mg at 500 mg per capsule and 90 capsules per bottle.
Add NMN 500mg to cart · $49.99
Is NatureWise berberine any good?
It is a sensible blend: 1,000 mg of a berberine complex (550 mg phytosome and 450 mg HCl) with turmeric, enzymes and black pepper extract, for $1.17 a day. The phytosome may help absorption, but its label weight includes phospholipid, so you can’t tell exactly how much berberine you get. If you want a plain berberine HCl dose you can adjust, a single-ingredient capsule such as our Berberine HCl 500mg costs $0.56 a day.
Is NatureWise a good probiotic brand?
NatureWise sells several probiotics, including 60 and 70 billion CFU formulas from $15.99, a Max Care formula and chewable oral probiotics from $16.99. Its Probiotics for Women was out of stock when we checked. CFU count alone doesn’t tell you much. Check which strains a formula names before you compare prices.
The Bottom Line
NatureWise is good at what it set out to do, which is inexpensive everyday supplements, and it did not set out to build a longevity range. Its two relevant products are blends at $1.17 a day. If you want single precursors and compounds at a cost per day you can calculate, our range is built for that.
More Brand Reviews and Guides
- Solaray review
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- Pure Encapsulations review
- Tru Niagen review
- Best NMN supplements
- Shop the Eternal Elixir range
Sources
- Vitamins Online, Inc. v. HeartWise, Inc., d/b/a NatureWise, Nos. 20-4126 and 21-4152 (10th Cir. June 27, 2023). Opinion (govinfo.gov)
- Liu CS, et al. Research progress on berberine with a special focus on its oral bioavailability. Fitoterapia. 2016. PubMed 26851175
- Martens CR, et al. Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults. Nat Commun. 2018. PubMed 29599478
- Christen S, et al. The differential impact of three different NAD+ boosters on circulatory NAD and microbial metabolism in humans. Nat Metab. 2026. PubMed 41540253
- Yin J, et al. Efficacy of berberine in patients with type 2 diabetes mellitus. Metabolism. 2008. PubMed 18442638
- Product pages, checked September 2026: NatureWise Berberine, NatureWise NAD+ Support Complex, NatureWise shipping policy, Eternal Elixir Berberine HCl 500mg, Eternal Elixir Nicotinamide Riboside 500mg
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
